Plantersville is a town in Lee County, Mississippi. The population was 868 at the 2020 census. Plantersville is located at 34°12′42″N 88°39′49″W / 34.21167°N 88.66361°W. According to the United States Census Bureau, the town has a total area of 1.5 square miles, of which 1.4 square miles is land and 0.69% is water.