Pascagoula is a city in and the county seat of Jackson County, Mississippi, United States. It is the principal city of the Pascagoula metropolitan area, and is part of the Gulfport–Biloxi–Pascagoula Combined Statistical Area and the Gulfport-Biloxi metropolitan area. The population was 22,392 at the 2010 census, down from 26,200 at the 2000 census. In 2019 the population was 21,699.
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