The Cardinals open on the road and end the season with two consecutive road games. They have two prime-time games scheduled. They have their bye week in Week 8. In 2025, as an odd year, the entire NFC will have eight home games and nine road games. The AFC will have nine home games and eight road games.

Arizona returns to prime time this season with a Monday night game against Dallas in Week 9. It'll also be on Thursday Night Football for the first time since 2022, when it plays Seattle in Week 4. The Cardinals' revamped defense will be tested throughout the season, as it will face seven former No. 1 picks and four Heisman Trophy winners.