In their study, published in the journal Science Translational Medicine, the group found a certain conformation-specific antibody that would bind to tau proteins, placed it inside of a shell that ...

Merck & Co is looking to improve its neurology pipeline via a deal with Teijin Pharma to develop a new tau-targeting antibody. The tau protein is implicated in a number of nervous system ...

The concentrations of conformationally altered tau proteins in homogenized dissected areas of the brain were measured by ELISA using two different antibodies specific for tau protein alterations.

The team found that TTCM2 utilizes a naturally occurring protein in cells known as TRIM21, which functions as an intracellular antibody receptor – helping to mark the antibody-bound tau aggregates.

Scientists have only shifted focus more recently to developing anti-tau therapies. Of the tau aggregation inhibitors and antibodies that they have generated so far, many of them do not efficiently ...

Tau is a microtubule-associated protein encoded by the MAPT gene located on chromosome 17q21. It promotes microtubule assembly and stability and may play a role in establishing and maintaining ...

Recent studies implicate the immune system and a herpes virus as potential contributors to development of disease ...

Late-onset Alzheimer's disease is a debilitating, progressive neurodegenerative disease that affects about 7 million ...

Many vaccines work by introducing a protein to the body that resembles part of a virus. Ideally, the immune system will produce long-lasting antibodies recognizing that specific virus, thereby ...

“P-Tau can increase three- to seven-fold ... to isolate individual immunocomplexes (consisting of an antibody-bound target protein and fluorescent reporter enzyme), boosting sensitivity at ...

This manuscript describes the identification and characterization of 12 specific phosphomimetic mutations in the recombinant full-length human tau protein that trigger tau to form fibrils. This ...