Exercise may positively influence the interactions between brain cells in the hippocampus, a brain region involved in ...

Tau is a microtubule-associated protein that helps to stabilize the structure of neurons, specifically by supporting ...

Additionally, some of the therapeutic antibodies can cause serious side effects. Before I joined the group, the Eisenberg team used tau’s structure to design a six-residue, D-enantiomeric peptide ...

Tau protein is a microtubule-associated protein (MAP) known to stabilize the internal structure of neurons, binding to microtubules. These are microscopic tubular structures that support the ...

(Alzheimer's & Dementia) The Scientist explored the work of a researcher who had an unexpected finding while developing a novel anti-tau therapy. Nicotinamide was safe but did not alter Alzheimer ...

Figure 1: Direct and indirect pathological events that can contribute to tau-mediated neurodegeneration. Figure 2: The domain structure of the tau isoforms that are expressed in the adult human brain.

The possibility that Alzheimer’s disease diagnosis is associated with viruses, bacteria, fungi, and parasites has been ...

This manuscript describes the identification and characterization of 12 specific phosphomimetic mutations in the recombinant full-length human tau protein that trigger tau to form fibrils. This ...

The current human tissue-based study provides convincing evidence correlating hippocampal expressions of RNA guanine-rich G-quadruplexes with aging and with Alzheimer's Disease presence and severity.