Mayer, who hits seventh for the Red Sox, gave Boston an early lead in the second inning. With the game tied at 1-1, Mayer launched a first-pitch slider from Rays starter Zack Littell over the right-field wall at Fenway Park.

The possibly resurgent Sox (34-36) have won four of five and five of their last seven. They are off Thursday then open a three-game series against the Yankees at Fenway on Friday night.

Marcelo Mayer became the ninth-youngest Boston Red Sox player ever to go yard twice in a game at Fenway Park, belting two homers against the Tampa Bay Rays on Wednesday.