Researchers have developed a blood test based on a protein biomarker for tau tangles that can help diagnose Alzheimer’s disease and also provide insight on how far the disease has progressed.

In contrast, the study authors note, tau is not mutated in AD, which means future work is needed to see how mice with Alzheimer’s-like tangles respond to OLX-07010. Alzheimer’s is thought to ...

Source Reference: Islam T, et al "Phospho-tau serine-262 and serine-356 as biomarkers of pre-tangle soluble tau assemblies in Alzheimer's disease" Nat Med 2025; DOI: 10.1038/s41591-024-03400-0.

Detecting sites within that core region of 111 amino acids, a sequence they call tau 258-368, can identify clumping-prone tau proteins and help initiate further diagnostics and early treatment.

Alzheimer's-linked tau protein gets a surprising redemption story By Paul McClure September 01, 2024 The tau protein is not such a 'bad guy' after all Depositphotos View 3 Images View gallery - 3 ...

A spectrum of neurodegenerative diseases, including frontotemporal dementia (FTD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are due to the accumulation of abnormal, ...

The irregular buildup of tau protein in the brain can form “tangles,” which researchers link to several brain disorders, including Alzheimer’s disease. This may have implications for ...

a The presence of extracellular β-amyloid deposition as neuritic plaques and the intracellular accumulation of hyperphosphorylated tau as neuro fibrillary tangles remain the primary neuropathologic ...

Tangles are the result of a build-up of tau protein inside neurons. In a healthy brain, tau binds with the neurons’ internal structures, microtubules, which help disperse nutrients throughout ...

Detection and evaluation of tau proteins (Tau) and fibrillary tangles has been a focus in the field of neurodegeneration (ND) due to the high correlation with pathogenesis. Here, a novel approach is ...

Alzheimer's disease is characterized by the deposition of amyloid plaques and neurofibrillary tau tangles in the brain. In recent years, several plasma biomarkers have been developed to assess these ...