Mapping a key protein in the brain in Alzheimer’s disease Researchers ... A PhD student at the University of Exeter will look at ways to reduce tau tangles by targeting immune cells in the brain. If ...

Participants underwent several tests, including: Brain PET scans to detect amyloid plaques and tau tangles—two proteins that build up in the brains of Alzheimer’s patients. MRI scans to ...

When scientists examined his brain scans, they noticed something unusual. In most Alzheimer’s patients with his mutation, toxic proteins called tau tangles spread throughout the brain, damaging ...

Two key biomarkers, amyloid protein, found in plaques, and tau protein, found in tangles, became the targets outside of the brain tissue itself, since their presence in the brain defines the disease.

Along with another protein, amyloid beta, tau can build up in the brain and disturb cell function. Irregular clumps of tau are called neurofibrillary tangles, which are a hallmark of Alzheimer’s.

As Chui explains, “tangles” are irregular accumulations of the protein tau, and this phenomenon is what causes the observable impairments in the abilities of Alzheimer’s patients to perform certain ...

A biomarker test developed at the University of Pittsburgh can detect small amounts of clumping-prone tau protein years before it appears on brain scans, enabling early diagnosis of Alzheimer’s ...