A biomarker test identified tau pathology in Alzheimer's disease before fibrillary tangles developed. Neurofibrillary tangle formation can be prevented by targeting intermediate soluble tau ...

For example, Alzheimer's disease is usually characterized by an equal proportion of both tau isoforms, whereas fibrillary tangles in progressive supranuclear palsy and Pick's disease consist ...

A team of researchers at the Case Western Reserve University School of Medicine has taken a major step toward understanding the mechanisms involved in the formation of large clumps of tau protein, a ...

For example, Alzheimer's disease is usually characterized by an equal proportion of both tau isoforms, whereas fibrillary tangles in progressive supranuclear palsy and Pick's disease consist ...

Similar tangles of tau, which spread among nerve cells, are also associated with a host of other neurodegenerative diseases, collectively known as "tauopathies." ...

In Alzheimer’s disease, clumps of a tau protein begin to form inside nerve cells in the brain. Brain accumulation of these aggregates is known as “neurofibrillary tangles.” Similar tangles of tau, ...

a The presence of extracellular β-amyloid deposition as neuritic plaques and the intracellular accumulation of hyperphosphorylated tau as neuro fibrillary tangles remain the primary ...

A team of researchers at the Case Western Reserve University School of Medicine has taken a major step toward understanding the mechanisms involved in the formation of large clumps of tau protein ...

By measuring the level of phosphorylation at specific sites on the tau protein, particularly p-tau262 and p-tau356 (shown here, researchers can gain insight into the early stages of tau aggregation.

Positron emission tomography (PET) scans are good at spotting tangles of tau protein, but this, too, is a problem—they only really catch fully formed clumps of tau. Credit: Jens Maus/Wikimedia ...

Researchers have found that when used on monkeys, an experimental drug slowed the process that leads the tau protein to aggregate into neuron-damaging tangles in Alzheimer’s disease. The next ...

In Alzheimer's disease, clumps of a tau protein begin to form inside nerve cells in the brain. Brain accumulation of these aggregates are known as "neurofibrillary tangles." Similar tangles of tau, ...