Ooh, that’s a big one,” Donald Trump said Monday as he signed an executive order – one of dozens during his first hours as president – to withdraw the United States from the World Health Organization.

The U.S. has traditionally been the most generous benefactor of the WHO. A Trump executive order to cut ties with the WHO could pose a threat to global public health.

Questions remain and reactions from world leaders are coming in after President Donald Trump signed an executive order to remove the United States as a member state of the World Health Organization. We look at the impacts.