Tau protein is essential for microtubule stability and neuronal function. The protein’s disfunction is linked to several ...

A new study published this month in Nature marks a key milestone in Alzheimer’s research. It demonstrates the first complete model of a tau filament, a protein structure found in the brain cells ...

Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder marked primarily by β-amyloid (Aβ) deposition and abnormal ...

Tau is a microtubule-stabilizing protein that aggregates in several neurodegenerative diseases. In this Review, Wang and Mandelkow describe the structure, expression and post-translational ...

The distinct structures of toxic protein aggregates that form in degenerating brains determine which type of dementia will occur, which regions of brain will be affected, and how quickly the disease ...

The Scheres group resolved the tau protein structure at a resolution of 3.4 - 3.5 angstroms, where an angstrom is 1 ten-billionth of a meter in size. The scientists were then able to model the ...

This structure solves the riddle of why Pick’s deposits exclude 4R tau, the authors noted. For 4R tau to assume this J configuration, the R2 domain would have to replace R1. However, the R2 domain ...

More than 90% of people with Down syndrome (DS) are diagnosed with Alzheimer’s disease (AD) by ages 55–60. However, it remains unknown whether there is a difference in the structure of amyloid ...

Aggregated tau protein is associated with over 20 neurological disorders, which include Alzheimer's disease. Previous work has shown that tau's sequence segments VQIINK and VQIVYK drive its ...

This experiment demonstrated that the structure of pathological tau aggregates alone is sufficient to account for most if not all the variation seen in human neurodegenerative diseases that are ...

Alzheimer's disease-associated CD83(+) microglia were linked with increased immunoglobulin G4 and human cytomegalovirus in the gut, vagal nerve, and brain. (Alzheimer's & Dementia) The Scientist ...

Structure of toxic tau aggregates determines type of dementia, rate of progression. ScienceDaily . Retrieved March 13, 2025 from www.sciencedaily.com / releases / 2016 / 10 / 161028205358.htm ...