The Philadelphia Phillies (23-16) and Cleveland Guardians (23-16) wrap up their 3-game series on Sunday Night Baseball. First pitch from Progressive Field in Cleveland is set for 7 p.m. ET (ESPN). Let's analyze BetMGM Sportsbook's MLB odds around the Phillies vs. Guardians odds and make our expert MLB picks and predictions for the best bets.

Zack Wheeler vs. Luis Ortiz is a complete mismatch in favor of the Phillies, who should beat the Guardians by multiple runs tonight, per our MLB betting picks for Sunday, May 11, 2025.

Preview the May 11 matchup between the Philadelphia Phillies and Cleveland Guardians with odds over/under, game spread, betting lines and more.