The Amyloid—Tangle Connection. Aβ aggregates (green) hyper-excite neurons in tau epicenters and connected regions, strengthening that connectivity. This pushes tau propagation from one region to ...

Jan. 15, 2025 — Most treatments being pursued today to protect against Alzheimer's disease focus on amyloid plaques and tau tangles that accumulate in the brain, but new research points to a ...

Chronic traumatic encephalopathy, or CTE, is a degenerative brain disease linked to repetitive head trauma. Here's how it ...

This manuscript describes the identification and characterization of 12 specific phosphomimetic mutations in the recombinant full-length human tau protein that trigger tau to form fibrils. This ...

A PhD student at the University of Exeter will look at ways to reduce tau tangles by targeting immune cells in the brain. If you have any queries about your magazine, get in touch with our Supporter ...

A serious knock to the head may also deliver an insidious blow to the human immune system – a one-two punch that could ...

Can head trauma cause Alzheimer’s? Yes, by reactivating dormant brain viruses like HSV-1, triggering inflammation and ...

This study examined whether sex, age, microglial activation or ApoE4 modulates the Aβ to p-tau axis, a critical event in the amyloid cascade that triggers the progression of Alzheimer’s disease (AD) ...

They found greater amounts of HSV-1 proteins among tau tangles, the clotted twists of tau protein which are known as one of the hallmarks of Alzheimer's disease. Doctors then created miniature ...

They found greater amounts of HSV-1 proteins among tau tangles, the clotted twists of tau protein which are known as one of the hallmarks of Alzheimer’s disease. Doctors then created miniature cell ...