Johnson & Johnson is advancing Alzheimer’s research through precision medicine, focusing on tau-targeting therapies like ...

In their study, published in the journal Science Translational Medicine, the group found a certain conformation-specific antibody that would bind to tau proteins, placed it inside of a shell that ...

The team found that TTCM2 utilizes a naturally occurring protein in cells known as TRIM21, which functions as an intracellular antibody receptor – helping to mark the antibody-bound tau aggregates.

Tau is a protein that is found in cells of the central ... Biogen and Eisai have already filed for approval of their amyloid-targeting antibody aducanumab, and while some analysts see the evidence ...

Scientists have only shifted focus more recently to developing anti-tau therapies. Of the tau aggregation inhibitors and antibodies that they have generated so far, many of them do not efficiently ...

Joseph Arboleda-Velasquez of Harvard Medical School praised the results. “Ye’s group has now provided compelling evidence showing increased binding affinity of ApoE3 Christchurch for tau and its ...

Prothena's antibody targets an area within the microtubule binding region (MTBR) of tau, which the Irish biotech reckons is most closely associated with the pathogenic spread of the protein and ...

In July 2024, the FDA approved a third antibody ... of amyloid and tau, which in turn leads to neurodegeneration. To tackle presumably harmful neuroinflammation and protein build-up, scientists ...

Conversely, a combination of function-blocking monoclonal antibodies to NGF ... into the locus encoding the microtubule-binding protein tau. We established a slice culture method for mid-gestation ...

Many vaccines work by introducing a protein to the body that resembles part of a virus. Ideally, the immune system will produce long-lasting antibodies recognizing that specific virus, thereby ...