They consist of aggregates of abnormally phosphorylated tau proteins that are altered in conformation. Conformational changes in tau proteins are thought to be the earliest neurobiological changes ...

The immunotherapy, which Lovell and his team developed, includes epitopes from both Aβ and tau proteins. These are mixed with special liposomes, or tiny fat bubbles, which help deliver the ...

Tau proteins with cysteine groups bearing thiol groups (S) undergo chemical changes under oxidative stress to form disulfide bonds, making a toxic mutant of the tau protein that can aggregate.

This manuscript describes the identification and characterization of 12 specific phosphomimetic mutations in the recombinant full-length human tau protein that trigger tau to form fibrils. This ...

Researchers from South Korea and the United States have found a new method to eliminate the tau protein, which is known to cause Alzheimer’s disease. The research team led by Lee Jeong-soo ...

A study from Washington University in St. Louis found taking suvorexant, a common insomnia medication, for two nights slightly decreased amyloid-beta and tau proteins linked to Alzheimer's.

It is these prion forms of Aβ and tau that are actually ... identification of disease-specific epitopes (antibody-binding sites) in misfolded prion-like proteins. Its proprietary platforms ...