This manuscript describes the identification and characterization of 12 specific phosphomimetic mutations in the recombinant full-length human tau protein that trigger tau to form fibrils. This ...

The current human tissue-based study provides convincing evidence correlating hippocampal expressions of RNA guanine-rich G-quadruplexes with aging and with Alzheimer's Disease presence and severity.

Tau is a microtubule-associated protein that helps to stabilize the structure of neurons, specifically by supporting ...

Appropriate use criteria (AUC) for the use of amyloid and tau positron emission tomography (PET) have been issued by the Alzheimer's Association and the Society for Nuclear Medicine and Molecular ...

(L-R) In green - herpes virus proteins. In red - Alzheimer’s tau. In orange - a merge of the two. (photo credit: Shemesh Lab) Alzheimer’s disease diagnosis depends on Neurofibrillary tangles ...

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss, often associated with the accumulation of amyloid plaques and tau protein ...

Their new research has also revealed how tau protein may initially protect the brain from the virus but later contributes to brain damage. The findings are published in Cell Reports in an article ...

A study from Washington University in St. Louis found taking suvorexant, a common insomnia medication, for two nights slightly decreased amyloid-beta and tau proteins linked to Alzheimer's.

The study results are published today in Cell Reports. The study also revealed how tau protein, often viewed as harmful in Alzheimer’s, might initially protect the brain from the virus but ...

Additionally, the tau protein, known for its association with neurodegenerative diseases, has been shown to form cohesive envelopes around microtubules. These envelopes are influenced by the ...

Modified tau protein was found colocalized with viral proteins, particularly in advanced disease stages. When brain cells were infected with HSV-1, tau became modified through phosphorylation ...

This p-tau then suppressed ICP27, hinting that neurons may initially ramp up p-tau production to combat viral infection. Expression of herpes simplex protein ICP27 is elevated in AD brain. In infected ...