This manuscript describes the identification and characterization of 12 specific phosphomimetic mutations in the recombinant full-length human tau protein that trigger tau to form fibrils. This ...

The current human tissue-based study provides convincing evidence correlating hippocampal expressions of RNA guanine-rich G-quadruplexes with aging and with Alzheimer's Disease presence and severity.

This p-tau then suppressed ICP27, hinting that neurons may initially ramp up p-tau production to combat viral infection. Expression of herpes simplex protein ICP27 is elevated in AD brain. In infected ...

New study led by Prof Karen Duff, Dr Naoto Watamura, & Dr Martha Foiani (UK DRI at UCL) with Prof Takaomi Saido (Riken Center for Brain Science, Japan) reveals insight into the early stages of toxic ...

Proteinuria is the presence of too much protein in the urine. It is typically a sign of kidney disease, often in people diagnosed with diabetes, but also can occur with pregnancy, lupus, and other ...

Altered cerebrospinal fluid (CSF) levels of amyloid-β (Aβ) and tau proteins have been found in PDD, with intermediate changes for Aβ42 in non-demented PD. The authors investigated whether AD-related ...

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Their study suggests that the tau protein, typically seen as detrimental, might initially act as a defensive mechanism in the brain. This groundbreaking finding opens up new possibilities for ...

UCLH has recruited the first participant to a global study of a new drug in early development, called NI0752, which is thought to reduce the production of a protein in the brain called tau. People ...

Modified tau protein was found colocalized with viral proteins, particularly in advanced disease stages. When brain cells were infected with HSV-1, tau became modified through phosphorylation ...