Tau is a microtubule-stabilizing protein that aggregates in several neurodegenerative diseases. In this Review, Wang and Mandelkow describe the structure, expression and post-translational ...

Tau protein is essential for microtubule stability and neuronal function. The protein’s disfunction is linked to several ...

A new study published this month in Nature marks a key milestone in Alzheimer’s research. It demonstrates the first complete model of a tau filament, a protein structure found in the brain cells ...

Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder marked primarily by β-amyloid (Aβ) deposition and abnormal ...

Researchers from the Medical Research Council's Laboratory of Molecular Biology, Cambridge, UK, have solved the structure of the dementia-causing ‘tau’ protein in unprecedented detail. Using brain ...

Structure of toxic tau aggregates determines type of dementia, rate of progression. ScienceDaily . Retrieved March 13, 2025 from www.sciencedaily.com / releases / 2016 / 10 / 161028205358.htm ...

Aggregated tau protein is associated with over 20 neurological disorders, which include Alzheimer's disease. Previous work has shown that tau's sequence segments VQIINK and VQIVYK drive its ...

This structure solves the riddle of why Pick’s deposits exclude 4R tau, the authors noted. For 4R tau to assume this J configuration, the R2 domain would have to replace R1. However, the R2 domain ...

This experiment demonstrated that the structure of pathological tau aggregates alone is sufficient to account for most if not all the variation seen in human neurodegenerative diseases that are ...

More than 90% of people with Down syndrome (DS) are diagnosed with Alzheimer’s disease (AD) by ages 55–60. However, it remains unknown whether there is a difference in the structure of amyloid ...

Alzheimer's disease-associated CD83(+) microglia were linked with increased immunoglobulin G4 and human cytomegalovirus in the gut, vagal nerve, and brain. (Alzheimer's & Dementia) The Scientist ...