Tau is a microtubule-stabilizing protein that aggregates in several neurodegenerative diseases. In this Review, Wang and Mandelkow describe the structure, expression and post-translational ...

A new study published this month in Nature marks a key milestone in Alzheimer’s research. It demonstrates the first complete model of a tau filament, a protein structure found in the brain cells ...

Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder marked primarily by β-amyloid (Aβ) deposition and abnormal ...

Structure of toxic tau aggregates determines type of dementia, rate of progression. ScienceDaily . Retrieved March 13, 2025 from www.sciencedaily.com / releases / 2016 / 10 / 161028205358.htm ...

Tau protein is essential for microtubule stability and neuronal function. The protein’s disfunction is linked to several neurodegenerative diseases, such as AD, PD, and HD.

This structure solves the riddle of why Pick’s deposits exclude 4R tau, the authors noted. For 4R tau to assume this J configuration, the R2 domain would have to replace R1. However, the R2 domain ...

More than 90% of people with Down syndrome (DS) are diagnosed with Alzheimer’s disease (AD) by ages 55–60. However, it remains unknown whether there is a difference in the structure of amyloid ...

Tau Structure, Isoforms, and Localization. Tau’s structural diversity arises from alternative splicing of the MAPT gene, which produces six isoforms that differ in the number of amino (N)-terminal ...

Alzheimer's disease-associated CD83(+) microglia were linked with increased immunoglobulin G4 and human cytomegalovirus in the gut, vagal nerve, and brain. (Alzheimer's & Dementia) The Scientist ...

Before I joined the group, the Eisenberg team used tau’s structure to design a six-residue, D-enantiomeric peptide (6-DP). However, the group hypothesized that this tau aggregation inhibitor would not ...

The distinct structures of toxic protein aggregates that form in degenerating brains determine which type of dementia will occur, which regions of brain will be affected, and how quickly the disease ...